الهام عبد الجبوري ( أستاذ مساعد )
كلية التربية للبنات - الكيمياء
[email protected]
Oxytocin: New and Effective Biochemical Marker for The Detection of Metabolic Syndrome
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الهام عبد مهدي اسم الناشر:
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(lytics(Thomson Reuters)USA) Journal score value :3.56,MJLClarivateAnaISSN:0976-0997,NAAS Rated  
2019 سنة النشر:


Abstract Metabolic syndrome (MS) is the medical term for a cluster of metabolic abnormalities that increases in the individuals risk of T2DM and CVD. The symptoms of MS including: glucose intolerance, obesity, hypertension and dyslipidemia. Recently oxytocin played important role in metabolism and energy balance, additionally, it has interested potential as metabolic disease therapeutic. The present study aimed to evaluate oxytocin levels in sera of studied groups and study its effect on the metabolic disorders. 50 metabolic syndrome patients were enrolled in the present work, in addition to 50 cases suffered at least one of the metabolic syndrome symptoms as pathological control, finally these groups were compared to 50 healthy individuals. Competitive ELISA was applied for evaluation of oxytocin concentration in sera samples of the study groups. ANOVA test showed a highly significant variations of oxytocin levels among study groups, no significant differences were shown when the comparison was carried out between two genders of the same subgroups. Negatively correlations recorded between serum oxytocin levels and independent risk factors such as body mass index (BMI),triglyceride (TG), and low density lipoproteins binding cholesterol (LDL-C),while was positive correlation between oxytocin levels and high density lipoprotein binding cholesterol(HDL-C), which proved that oxytocin might be participated in carbohydrate homeostasis and lipid metabolism. Keywords: Metabolic syndrome, oxytocin, hypertension, insulin resistance, and dyslipidemia.