الهام عبد الجبوري ( أستاذ مساعد )
كلية التربية للبنات - الكيمياء
[email protected]
The Relationship Between Oxidative Stress and Antioxidant status in Beta Thalassemia Major Patients.
بحث النوع:
علوم التخصص العام:
الهام عبد مهدي اسم الناشر:
اسماء المساعدين:
جامعة القادسية الجهة الناشرة:
مجلة القادسية  
2014 سنة النشر:


In beta thalassemia decreased or impaired biosynthesis of beta –globin leads to accumulation of unpaired alpha globin chains. Excess presence of the alpha globin in chains is the primary reason for the cellular oxidative damage in thalassemia and also iron overloading as a result of both high plasma iron and intracellular non hemoglobin iron in beta thalassemia leads to enhanced generation of reactive oxygen species and oxidative stress. Blood samples were collected from (100) subjects (50 beta thalassemia major patients and 50 healthy controls), the range of age (4-18 years). The goal of the present investigations was to study the relationship between oxidative stress by measuring the malonyldialdehyde level which is the marker of oxidative stress in thalassemia major patients and serum trace elements (Fe,Cu, Zn, Se) and the role of antioxidant enzymes including superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GSH), glutlathione Peroxidase (GPX) in thalassemia blood samples. From obtained result it was cleared that plasma (MDA) levels was higher whereas erythrocyte SOD, CAT, GSH, GPX, levels were decreased in thalassemic patients as compared to the normal controls, There were significant changes in the values of (Se, Zn, Cu and Fe) between two groups, observed increase levels of (Fe) and (Cu),whereas decrease levels of (Zn) and (Se) in group of beta thalassemia when compared with group of controls. The administration of selective antioxidant along with essential trace elements and minerals to reduce the extent of oxidative damage and related complications in beta thalassemia major still need further evaluation.