الخلاصة

Siglecexpressionhasbeenobservedonspermfromseveralspeciesincludinghumans,cowsandsheep(Alkhodairetal.,2018).ThemajorfocusofSiglecresearchhasbeenontheimmunesystem(Crocker&Varki2001a,Crocker&Varki2001b,Crockeretal.2007)withmuchoftheworkconductedonhumansandmice.AnadvantageofusingmiceintheanalysisofSiglecfunctionistheeasebywhichexperimentscanbeconductedaswellastheabilitytogeneratespecificgeneticknockoutanimalmodelsifrequired(Lietal.2013,Thomasetal.2017).Inmice,Siglecshavehistoricallybeennameddifferentlytootherspecieseveniftheyhaveinfactorthologues.FiveSiglecs,Sialoadhesin(Siglec1),CD22(Siglec2),CD33(Siglec3),MAG(Siglec4)andSiglec15arehighlyconservedwithhumanforms.SiglecE,FandG,whilenottruehumanorthologues,areprobableparalogsofSiglec9,8and10respectively.Finally,SiglecHisuniquetothemouse.AsimilarrangeofSiglecshasbeenidentifiedintheratandincludesSiglec1,2,4,E,F,H,G(Varki&Angata2005).Overall,thesemousemodelsneedtobeexploredingreaterdetailandmayproveusefulinthestudyoftheroleofSiglecsintheMRTandFRT (15) (PDF) Siglec Expression on Sperm and Tissue from the Male Reproductive Tract in Mice and Rats. Available from: https://www.researchgate.net/publication/335210421_Siglec_Expression_on_Sperm_and_Tissue_from_the_Male_Reproductive_Tract_in_Mice_and_Rats [accessed Mar 24 2020].