Benner
د.حسن ثامر الشرعي ( أستاذ )
كلية التربية للبنات - اللغة العربية
[email protected]
07826502522
 
 
 
Synthesis and identification of some derivatives of 1,3,4-thiadiazole
تحميل
بحث النوع:
تربية التخصص العام:
Shaimaa Adnan اسم الناشر:
Ahmed Jasim Mohammed* and Hassan Thamer* اسماء المساعدين:
Ahmed Jasim Mohammed* and Hassan Thamer* الجهة الناشرة:
7(10): 1000-1011  
2015 سنة النشر:

الخلاصة

This research involved synthesis heterocyclic compounds such as (1,3,4- thiadiazole derivatives , imidazolidine derivatives, tetrazole derivatives, oxazepine derivatives and β-Lactam derivatives ) were prepared by reaction 4- aminobenzoic acid with phenol in Acidic medium ,(0-5)CO and sodium nitrate to get azo derivative (1) which react with thiosemicarbazide to get 1,3,4- thiadiazole derivative (2). Derivative (2) react with benzaldehyde derivatives (4-nitrobenzaldehyde , 2-hydroxy benzaldehyde , 2-bromobenzaldehyde , 4-hydroxybenzaldehyde ,benzaldehyde ,4- dimethyl amino benzaldehyde, 4-Chlorobenzaldehyde and vanillin) to get shiff base (3-10). The cyclization of Shiff base Derivatives (3,4) with α-aminoacid (tryptophan and leucine) Consecutive give the corresponding imidazolidine derivatives (11,12),and when cyclization of Shiff base Derivative (5) with sodium azide give tetrazole derivative (13). Shiff base Derivatives (6,7,8) react with (Itaconic, succinic anhydride and malic anhydride ) Co nsecutive to give oxazepine derivatives (14,15,16) Consecutive. cyclization of Shiff base Derivatives (9,10) with chloroacetylchloride give the corresponding β-lactam (17,18). All this compounds characterized by means of FTIR, and some of the compoundes by means 1H-NMR, and 13C-NMR and follow reaction by Rf - TLC and Measure ment melting point. Key words: Thiadiazole, Thiazolidin, Imidazolidin, tetrazole, oxazepine β-Lactam