Benner
د.حسن ثامر الشرعي ( أستاذ )
كلية التربية للبنات - اللغة العربية
[email protected]
07826502522
 
 
 
Synthesis some of heterocyclic Compounds of Meldrum ' s Acid and study of The biological Activity
تحميل
بحث النوع:
تربية التخصص العام:
Rajaa Abdul Ameer اسم الناشر:
Naji Mousa Ali and Hassan T. Ghanim3 اسماء المساعدين:
International Journal Of Advanced Research In Medical & Pharmaceutical Sciences الجهة الناشرة:
Volume.3,Issue.6,June.2018  
2018 سنة النشر:

الخلاصة

This paper involves synthesis of some heterocyclic compound derivative from Meldrum' s acid ,by reaction of Meldrum' s acid , indol and p-hydroxy benzaldehyde and catalyst L-proline in acetonitrile to produce Meldrum's acid derivative (P),compound (P) ethanolysis to give ester derivative (P1),the compound (P1) reacted with hydrazine hydrate to give hydrazide derivative compound (P2) ,hydrazide derivative reacted with p-hydroxy benzaldehyde in absolute ethanol to give Schiff base derivative(P3), Schiff base derivative using to prepare some new heterocyclic compounds by multi step reactions and reactant with different solvent and materials to prepare four ,five and seven ring membered . The prepared compounds were characterized by FT-IR ,H1NMR,13CNMR .All the prepared compounds were studied the antibacterial activity . Keywords : indo , comp , character . I.INTRODUCTION