Benner
هناء جعفر الكعبي ( أستاذ مساعد )
كلية
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Synthesis, Characterization, and Antibacterial Study of New Ligands Derived from Nalidixic acid
تحميل
بحث النوع:
علوم التخصص العام:
Dunya AL-Duhaidahawi1 اسم الناشر:
Hanaa Jaffer AlKabee2 Meison Abdulbary3, Hayder H. AL-Ghuraibawi4 اسماء المساعدين:
Systematic Review Pharmacy الجهة الناشرة:
A multifaceted review journal in the field of pharmacy  
2020 سنة النشر:

الخلاصة

A novel compounds of nalidixic acid derivatives were synthesized by a coupling reaction with 2-aminothiazole-5-carbaldehyde using DIC as coupling reagent and HOBt as racemization suppressant then the product of reaction treated with different amine tail like 2-(methylthio) Ethan amine that result in compound 1 while refluxing with 2-(4-methyl piperazine-1-yl) Ethan amine and 2-(pyrrolidine-1-yl) Ethan amine results in compound 2 and 4 respectively. All the synthesized compounds were adequately identified by spectral studies utilizing IR and elemental analysis and assessed for their in vitro antibacterial activity in contradiction of different type of bacteria. All the tested molecules against bacterial strains compared with the nalidixic acid as a reference drug in this study. Results indicated that compounds 1, 2 & 4 have good antibacterial activities compared to standard drug especially as they were found to have promising activity against Bacillus and to be as effective as nalidixic acid toward psudomonus and E coli.