Benner
فلاح شريف الخفاجي ( أستاذ )
كلية الصيدلة - صيدلة عام ( رئيس القسم )
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Anticancer Drug 5-Fluorouracil in Aqueous Solution by Differential Pulse Polarography: An Assessment of Optimum Conditions
تحميل
بحث النوع:
علوم التخصص العام:
Razzaq Abd Al-Zahra Ibrahim اسم الناشر:
Hussein Kadhem Al-Hakeim and Falah Shareef Abed Suhail اسماء المساعدين:
Nano Biomedicine & Engineering . 2018, Vol. 10 Issue 3, p117-128. 12p. 2 Diagrams, 3 Charts, 9 Graph الجهة الناشرة:
Nano Biomedicine and Engineering. Copyright © 2009-2019 OAHOST, Publication and Conference Management by Scientists and for Scientists. © Shanghai Jiao Tong University Press  
2018 سنة النشر:

الخلاصة

The potassium phosphate buffer as a supporting electrolyte of anticancer drug (5-fluorouracil (5- FU)) was the best among solutions of sodium phosphate buffer and Britton Robinson buffer in differential pulse polarography (DPP) at pH = 7.0 and T = 37 °C. The changes of temperature did not effect on inactivity of the supporting electrolyte (potassium phosphate buffer at T = 10-50 °C), and pH of the solution did not exceed 2% of each 5 °C (at pH = 7.0, by modified thermostat cell). However, the frequency measurements showed clear effect of temperature on diffusion current (IP / μA) of the chemotherapy compound in the range of 20-50 °C and under primary conditions. Then, the polarography measurements of 5-FU drug (at 10 μM, pH = 7 and T = 37 °C) gradually led to the optimum conditions: deposition potential =-0.9 V; drop size = 9.0 mm3; deposition time = 15.0 s; equilibration time = 5.0 s; pulse amplitude = 100 mV; pulse time = 7.0 ms; voltage step = 6 mV; voltage step time = 0.3 s; and sweep rate = 20.0 mV/s. The thermal assessment of 5-FU drug (after achievement of the optimum conditions) in a new thermostat vessel at HMDE by DPP showed that the reaction of 5-FU molecules represented pseudo first order reaction, instead of first order); the secondary waves of 5-FU drug may be due to formation of molecular complexes in aqueous solution and the reduction of 5-FU molecules at mercury surface electrode appeared as physisorption, instead of chemisorption. Copyright of Nano Biomedicine & Engineering is the property of Open Access House of Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.