دنيا لفته الدحيدحاوي ( أستاذ مساعد )
كلية الصيدلة - صيدلة عام
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Macrocoumarin as novel antioxidants
بحث النوع:
صيدلة التخصص العام:
Dunya L. AL-Duhaidahawi اسم الناشر:
Yasameen K. Al-Majedy, Hiba H. Ibraheem, AbdulAmir H. Kadhum and Ahmed A. Al-Amiery2 اسماء المساعدين:
Oriental journal of chemistry الجهة الناشرة:
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2018 سنة النشر:


The present work pointed at the design and synthesis of novel coumarin compounds as antioxidants. The alteration of 4-hydroxycoumarin by several reaction levels was performed to generate destination compounds. Spectroscopic methods like Infrared Spectra FT-IR, 1H-NMR and 13CNMR, elemental analysis techniques, melting point, and thin layer chromatography defined the structure of the prepared compounds. The antioxidant activities of individual compounds were tested against stable free radical 1,1-Diphenyl-2-picrylhydrazyl radical (DPPH), hydrogen peroxide (H2O2) and FRAP (ferric reducing antioxidant power) and the results were related to the Gallic acid, ascorbic acid and Trolox as standards. The effects revealed that most of the syntheses presented greater activity as an antioxidant than the standards in different concentration range. The distinguished competence inactivating action was observed for compound 2 (86.3±1%) followed by compounds 3 (85±0.5%) using DPHH method. The antioxidant mode of action of the prepared compounds was also investigated.