Benner
دنيا لفته الدحيدحاوي ( أستاذ مساعد )
كلية الصيدلة - صيدلة عام
[email protected]
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Synthesis of New Poly Amide linked Heterocyclesas G-quadruplex Stabilizing Agents.
تحميل
بحث النوع:
صيدلة التخصص العام:
Kawkab Saour اسم الناشر:
Dunya lafta اسماء المساعدين:
International Journal of Pharmaceutical Sciences Review and Research الجهة الناشرة:
Available online at www.globalresearchonline.net  
2015 سنة النشر:

الخلاصة

In this study, we report novel compounds as polyamide compounds with aliphatic tertiary amine tail, compounds synthesized by conventional solution method employing DIC/HOBT as coupling system. The building block molecule was obtained by Chan-lam mediated oxidative coupling reaction in air; the biological activity against a panel of cancer cell line was assessed using SRB method. The results from preliminary assay indicated that introducing of imidazole heterocyclic unit instead of pyrrole in Distamycine significantly enhance the binding affinity with the quadruplex. The stabilization of non-canonical form was estimated with FRET DNA Technology using different sequences such as F21T, c-Myc, c-kit1 and c-kit2. Two member compounds (6 & 7) showed to be very selective in stabilizing one particular G-Quadruplex