الخلاصة

In this study, we report novel compounds as polyamide compounds with aliphatic tertiary amine tail, compounds synthesized by conventional solution method employing DIC/HOBT as coupling system. The building block molecule was obtained by Chan-lam mediated oxidative coupling reaction in air; the biological activity against a panel of cancer cell line was assessed using SRB method. The results from preliminary assay indicated that introducing of imidazole heterocyclic unit instead of pyrrole in Distamycine significantly enhance the binding affinity with the quadruplex. The stabilization of non-canonical form was estimated with FRET DNA Technology using different sequences such as F21T, c-Myc, c-kit1 and c-kit2. Two member compounds (6 & 7) showed to be very selective in stabilizing one particular G-Quadruplex