الخلاصة

The study was conducted to investigate the difference in the serum malondialdehyde (MDA), glutathione (GSH), and peroxy nitrate (PN) levels between type 2 (T2DM) diabetes patients and normal subjects. MDA, GSH, and PN levels in sera of 100 patients and 80 participants in the control group were evaluated. A statistically significant difference was found between patients and the control group in terms of MDA, GSH, and PN levels. A decrease in GSH activity was detected (P<0.0001), while MDA and PN levels increased significantly (P<0.0001). The high levels of patients versus control ratio of MDA and PN levels probably suggests the occurrence as a mechanism of tissue damage in cases of T2DM. Moreover, it is recommended that the patient levels of MDA, GSH, and PN should be evaluated in insulin resistance patients.