Benner
اثير محمد الزرفي ( مدرس مساعد )
كلية الصيدلة - صيدلة عام
[email protected]
 
 
 
PREPARATION AND CHARACTERIZATION OF ORODISPERSIBLE TABLETS OF CANDESARTAN CILEXETIL BY DIRECT COMPRESSION METHOD
تحميل
بحث النوع:
صيدلة التخصص العام:
ATHEER MOHAMMED JASEM اسم الناشر:
MOWAFAQ MOHAMMED GHAREEB اسماء المساعدين:
International Journal of Pharmacy and Pharmaceutical Sciences الجهة الناشرة:
Academic Sciences  
2013 سنة النشر:

الخلاصة

Objective: Candesartan cilexetil (CC) is a selective AT1 subtype angiotensin II receptor antagonist and candesartan is widely used in treatment of diseases like hypertension, heart failure, myocardial infarction and diabetic nephropathy. The objective of this study was to prepare and evaluate orodispersible tablets of candesartan cilexetil using direct compression method. The orodispersible tablets (ODT) as recently developed drug delivery system is a solution for many problems faced by patients especially the pediatric and geriatrics. Methods: The tablets were made using different superdisintegrant [Sodium Starch Glycolate (SSG) and Croscarmellose Sodium (CCS), and Crospovidone (CP)] at three different percentages, in addition to sweetening agent (aspartame) with microcrystalline cellulose (MCC) and mannitol as diluents. Formulated orodispersible tablets were evaluated for weight variation, friability, disintegration time, drug content, wetting time, water absorption ratio and in vitro drug release. Results: The results show that the presence of a superdisintegrant and MCC is desirable for orodispersion. Although all the formulations satisfied the limits of orodispersion with a dispersion time of less than 48 sec but formula (F8) that contain 10% crospovidone as superdisintegrant with 30% MCC shows the best results regarding disintegration time of 13 sec, hardness of 3.5 kg/cm2, and fast drug release rate of 100% within 10 min, as compared with the conventional tablet (35%).