Benner
أسعد هاشم السالم ( مدرس مساعد )
كلية
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07810678034
 
 
 
Synthesis, Identification and study of the biological activity of some new aminoacetylenic isoindoline-1, 3-dione derivatives‏
تحميل
بحث النوع:
علوم التخصص العام:
Asaad Hashim Eneid اسم الناشر:
Naji Musa Ali اسماء المساعدين:
Journal of Kufa for Chemical Science الجهة الناشرة:
ISSN: 20772351 Publisher: University of Kufa Faculty: Eduction for Women Language: Arabic and English  
2012 سنة النشر:

الخلاصة

A number of aminoacetylenic isoindoline-1,3-dione (phthalimide) were prepared through the reaction of phthalimide with potassium hydroxide then alkylation process were carried out for this salt in order to afford N-propargylphthalimide(A1) .The Mannich reaction (three component one pot reaction) was carried out by using the N-propynylphthalimide (A1), with different aldehydes in presence of morpholine or piperidine, as a secondary amines, to yield the desired compounds(A2-A6).The FT-IR, 1HNMR and elemental analysis were consistent with the assigned structures, these compounds also have been tested biologically against bacteria Proteus vulgaris.